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    Rcc1 regulator of chromosome condensation 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682908, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rcc1provided by RGD
    Official Full Name
    regulator of chromosome condensation 1provided by RGD
    Primary source
    RGD:1592835
    See related
    Ensembl:ENSRNOG00000050106 AllianceGenome:RGD:1592835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 70.3), Testes (RPKM 51.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149810037..149828475, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144526025..144544445, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150508840..150531062, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102992 Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene phosphatase and actin regulator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Chen T, et al. Nat Cell Biol, 2007 May. PMID 17435751, Free PMC Article
    2. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. Ohtsubo M, et al. Genes Dev, 1987 Aug. PMID 3678831
    3. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA. Ohtsubo M, et al. J Cell Biol, 1989 Oct. PMID 2677018, Free PMC Article
    4. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Bischoff FR, et al. Nature, 1991 Nov 7. PMID 1944575
    5. Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. Li HY, et al. Genes Dev, 2004 Mar 1. PMID 15014043, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187541

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosomal DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of chromosome condensation

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128189.2 → NP_001121661.1  regulator of chromosome condensation

      See identical proteins and their annotated locations for NP_001121661.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160834
      UniProtKB/TrEMBL
      A0A0G2K7T1, B1H227, M0R942
      Related
      ENSRNOP00000066003.1, ENSRNOT00000075127.2
      Conserved Domains (1) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149810037..149828475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593627.3 → XP_017449116.1  regulator of chromosome condensation isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    2. XM_063288406.1 → XP_063144476.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      B1H227, M0R942

    3. XM_017593629.3 → XP_017449118.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7T1, B1H227, M0R942
      Conserved Domains (1) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    4. XM_017593626.3 → XP_017449115.1  regulator of chromosome condensation isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    5. XM_039110774.2 → XP_038966702.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7T1, B1H227, M0R942
      Conserved Domains (1) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    6. XM_039110773.2 → XP_038966701.1  regulator of chromosome condensation isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Related
      ENSRNOP00000081871.1
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    7. XM_063288405.1 → XP_063144475.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      B1H227, M0R942

    8. XM_017593624.3 → XP_017449113.1  regulator of chromosome condensation isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    9. XM_063288407.1 → XP_063144477.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      B1H227, M0R942

    10. XM_006239073.5 → XP_006239135.1  regulator of chromosome condensation isoform X1

      See identical proteins and their annotated locations for XP_006239135.1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    11. XM_006239077.5 → XP_006239139.1  regulator of chromosome condensation isoform X2

      See identical proteins and their annotated locations for XP_006239139.1

      UniProtKB/TrEMBL
      A0A0G2K7T1, B1H227, M0R942
      Related
      ENSRNOP00000074333.2
      Conserved Domains (1) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    12. XM_008764173.4 → XP_008762395.1  regulator of chromosome condensation isoform X1

      See identical proteins and their annotated locations for XP_008762395.1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    13. XM_063288409.1 → XP_063144479.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      B1H227, M0R942

    14. XM_006239075.5 → XP_006239137.1  regulator of chromosome condensation isoform X1

      See identical proteins and their annotated locations for XP_006239137.1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    15. XM_039110777.2 → XP_038966705.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7T1, B1H227, M0R942
      Conserved Domains (1) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    16. XM_063288410.1 → XP_063144480.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      B1H227, M0R942

    17. XM_039110775.2 → XP_038966703.1  regulator of chromosome condensation isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7T1, B1H227, M0R942
      Related
      ENSRNOP00000091055.1
      Conserved Domains (1) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    18. XM_006239074.3 → XP_006239136.1  regulator of chromosome condensation isoform X1

      See identical proteins and their annotated locations for XP_006239136.1

      UniProtKB/TrEMBL
      A0A0G2K7T1, A0A8I5ZU07
      Conserved Domains (1) summary
      COG5184
      Location:19 → 432
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein Strain
    Heading Accession and Version

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